A-485
A-485 is a potent and selective small molecule inhibitor of the p300 and CBP histone acetyltransferases, with IC50 values of 9.8 nM and 2.6 nM, respectively. It has demonstrated antitumor activity in preclinical studies, including models of hematologic cancers and androgen receptor-positive prostate cancer, in both cellular and animal experiments.
Product Specifications
CAS Number
1889279-16-6
Product Name Alternative
CBP, CBP/p300, A485, A-485, A 485, Inhibitor, histone acetyltransferase, Histone Acetyltransferase, HistoneAcetyltransferase, HAT, HATs, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit, p300
Field of Research
Epigenetics & Chromatin
Purity
98.01% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.32 mM) ; DMSO:252.5 mg/mL (470.66 mM)
Smiles
CNC (=O) Nc1ccc2c (CC[C@@]22OC (=O) N (CC (=O) N (Cc3ccc (F) cc3) [C@@H] (C) C (F) (F) F) C2=O) c1
Molecular Formula
C25H24F4N4O5
Molecular Weight
536.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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