1'-Hydroxy bufuralol
1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1].
Product Specifications
CAS Number
57704-16-2
UNSPSC
12352005
Hazard Statement
H302
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/1-hydroxy-bufuralol.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O
Molecular Formula
C16H23NO3
Molecular Weight
277.36
Precautions
H302
References & Citations
[1]Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82 (4) :668-78.|[2]H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46 (3) :568-77.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2
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