1'-Hydroxy bufuralol

1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1].

Product Specifications

CAS Number

[57704-16-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-hydroxy-bufuralol.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O

Molecular Formula

C16H23NO3

Molecular Weight

277.36

Precautions

H302

References & Citations

[1]Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82 (4) :668-78.|[2]H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46 (3) :568-77.