Chroman 1
Chroman 1 is a highly potent and selective small molecule inhibitor of ROCK kinases, exhibiting sub-nanomolar IC50 values of 52 pM for ROCK1 and 1 pM for ROCK2. It is a valuable research tool for investigating Rho/ROCK signaling pathways in cardiovascular, neurological, and fibrotic disease models, applicable in both cellular and biochemical assays.
Product Specifications
CAS Number
1273579-40-0
Product Name Alternative
ROCK, ROCK1, ROK, ROCK2, Rho-kinase, rho kinase, Rho-associated protein kinase, Rho-associated kinase, spinal, inhibit, MRCK, glaucoma, injury, Inhibitor, cord, Chroman 1, Chroman1, Chroman-1
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.28% (May vary between batches)
Solubility
DMSO:50 mg/mL (114.55 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.56 mM)
Smiles
COc1ccc2OC[C@H] (Cc2c1) C (=O) Nc1ccc (cc1OCCN (C) C) -c1cn[nH]c1
Molecular Formula
C24H28N4O4
Molecular Weight
436.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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