CITCO
CITCO is a selective agonist of the constitutive androstane receptor (CAR) and an inhibitor of the pregnane X receptor (PXR) with an EC50 of 49 nM. This imidazothiazole derivative suppresses brain tumor stem cell (BTSC) proliferation and is utilized in vitro and in vivo to study nuclear receptor signaling in oncology and toxicology.
Product Specifications
CAS Number
338404-52-7
Product Name Alternative
PXR, inhibit, Inhibitor, CITCO, Apoptosis, CAR
Field of Research
Cell Biology
Purity
99.24% (May vary between batches)
Solubility
DMSO:11 mg/mL (25.19 mM) ; H2O:insoluble;10% DMSO+90% Corn Oil:1 mg/mL (2.29 mM)
Smiles
C (=NOCC1=CC (Cl) =C (Cl) C=C1) C2=C (N=C3N2C=CS3) C4=CC=C (Cl) C=C4
Molecular Formula
C19H12Cl3N3OS
Molecular Weight
436.74
Storage Conditions
-20°C
Notes
For research use only.
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