CMPD101
CMPD101 is a potent, cell-permeable inhibitor of GRK2 and GRK3, with IC50 values of 18 nM and 5.4 nM respectively. It is a valuable research tool for investigating heart failure mechanisms and GRK signaling in both cellular and animal models, though it shows weaker activity against GRK1, GRK5, ROCK-2, and PKCα.
Product Specifications
CAS Number
865608-11-3
Product Name Alternative
Desensitization, CMPD 101, CMPD101, CMPD-101, failure, GRK2, GRK3, heart, Inhibitor, Neuron, inhibit, PKC, PKCα, Rho-associated protein kinase, Rho-associated kinase, Rho-kinase, ROK, ROCK, ROCK2, Protein kinase C
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.34% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.72 mM) ; DMSO:250 mg/mL (535.95 mM)
Smiles
Cn1c (CNc2cccc (c2) C (=O) NCc2ccccc2C (F) (F) F) nnc1-c1ccncc1
Molecular Formula
C24H21F3N6O
Molecular Weight
466.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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