Rifabutin

Rifabutin is a semisynthetic ansamycin antibiotic that potently inhibits bacterial DNA-dependent RNA polymerase, blocking transcription initiation. It is widely used in antimycobacterial research, including in vitro susceptibility assays and in vivo models for studying tuberculosis and MAC infections.

Product Specifications

CAS Number

72559-06-9

Product Name Alternative

Bacterial, Antibiotic, Ansamycin, DNA Synthesis, DNASynthesis, inhibit, LM 427, LM427, LM-427, HSP90, Inhibitor, Endoplasmin, Rifabutin, RNASynthesis, RNA polymerase, RNA Synthesis

Field of Research

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.87% (May vary between batches)

Solubility

DMSO:50 mg/mL (59.03 mM) ; Ethanol:38 mg/mL (44.86 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.36 mM)

Smiles

CO[C@H]1\C=C/O[C@@]2 (C) Oc3c (C2=O) c2C4=NC5 (CCN (CC (C) C) CC5) NC4=C (NC (=O) \C (C) =C/C=C\[C@H] (C) [C@H] (O) [C@@H] (C) [C@@H] (O) [C@@H] (C) [C@H] (OC (C) =O) [C@@H]1C) C (=O) c2c (O) c3C