Streptozocin (Streptozotocin)
Streptozotocin is a GLUT2-transported antibiotic that selectively induces pancreatic β-cell apoptosis via DNA alkylation. It is extensively used to generate experimental models of diabetes in vivo and to study β-cell toxicity in vitro. Due to its instability, fresh preparation in solution is required.
Product Specifications
CAS Number
18883-66-4
Product Name Alternative
Streptozotocin; U-9889
Field of Research
Cell Biology
Purity
>97%
Bioactivity
Diabetes inducer; NO donor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml)
Smiles
[C@H] ([C@H] ([C@@H] ([C@@H] (CO) O) O) O) (NC (N (N=O) C) =O) C=O
Molecular Formula
C8H15N3O7
Molecular Weight
265.2
References & Citations
VI Sevastianov, AS Ponomareva, NV Baranova A Tissue-Engineered Construct Based on a Decellularized Scaffold and the Islets of Langerhans: A Streptozotocin-Induced Diabetic Model Life, (2024), N. V. Baranova et al. Impact of pancreatic cell-engineered constructs on the islet apparatus in recipient rats with type I diabetes mellitus researchgate.net, (2025)
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Deoxy-2-[[ (methylnitrosoamino) carbonyl]amino]-D-glucose
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