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DK419

DK419 is a potent, orally bioavailable small molecule inhibitor of the Wnt/β-catenin pathway (IC50 = 0.19 μM) . It downregulates key oncogenic targets including Axin2, β-catenin, c-Myc, Cyclin D1, and Survivin while activating pAMPK. This inhibitor is a valuable research tool for studying Wnt-driven cancers in both cellular and animal models.

Product Specifications

CAS Number

2102672-22-8

Product Name Alternative

Beta catenin, beta-catenin, betacatenin, DK419, DK-419, DK 419, bcatenin, Inhibitor, inhibit, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.15% (May vary between batches)

Solubility

DMSO:< 1 mg/mL (insoluble or slightly soluble)

Smiles

FC (F) (F) c1nc2cc (Cl) cc (C (=O) Nc3ccc (cc3) C (F) (F) F) c2[nH]1

Molecular Formula

C16H8ClF6N3O

Molecular Weight

407.7

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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