DK419
DK419 is a potent, orally bioavailable small molecule inhibitor of the Wnt/β-catenin pathway (IC50 = 0.19 μM) . It downregulates key oncogenic targets including Axin2, β-catenin, c-Myc, Cyclin D1, and Survivin while activating pAMPK. This inhibitor is a valuable research tool for studying Wnt-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
2102672-22-8
Product Name Alternative
Beta catenin, beta-catenin, betacatenin, DK419, DK-419, DK 419, bcatenin, Inhibitor, inhibit, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.15% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
FC (F) (F) c1nc2cc (Cl) cc (C (=O) Nc3ccc (cc3) C (F) (F) F) c2[nH]1
Molecular Formula
C16H8ClF6N3O
Molecular Weight
407.7
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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