Teniposide
Teniposide (VM-26) is a podophyllotoxin-derived chemotherapeutic agent that acts as a topoisomerase II inhibitor, stabilizing the enzyme-DNA complex to block DNA replication. It is widely used in cancer research, demonstrating activity in both in vitro cytotoxicity assays and in vivo models of leukemia and solid tumors.
Product Specifications
CAS Number
29767-20-2
Product Name Alternative
NSC 122819, inhibit, NSC122819, NSC-122819, Inhibitor, Topoisomerase, Topo II, Teniposide, VM26, VM-26, VM 26
Field of Research
Molecular Biology, Pharmacology & Drug Discovery
Purity
96.98% (May vary between batches)
Solubility
DMSO:125 mg/mL (190.36 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.05 mM)
Smiles
O=C1[C@@]2 ([C@@H] (C=3C ([C@@H] (O[C@@H]4O[C@]5 ([C@] ([C@H] (O) [C@H]4O) (O[C@@H] (OC5) C6=CC=CS6) [H]) [H]) [C@]2 (CO1) [H]) =CC7=C (C3) OCO7) C8=CC (OC) =C (O) C (OC) =C8) [H]
Molecular Formula
C32H32O13S
Molecular Weight
656.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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