Nilotinib
Nilotinib (AMN107) is an orally bioavailable, potent inhibitor of the Bcr-Abl tyrosine kinase. It demonstrates significant antitumor efficacy in both in vitro and in vivo models and is a key therapeutic agent for research on Imatinib-resistant chronic myelogenous leukemia (CML) .
Product Specifications
CAS Number
641571-10-0
Product Name Alternative
AMN-107
Field of Research
Cell Biology
Purity
>98%
Bioactivity
BCR-ABL inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml)
Smiles
C (F) (F) (F) C=1C=C (C=C (NC (=O) C2=CC (NC=3N=C (C=CN3) C=4C=CC=NC4) =C (C) C=C2) C1) N5C=NC (C) =C5
Molecular Formula
C28H22F3N7O
Molecular Weight
529.52
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-Methyl-N-[3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl]-3-[ (4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide
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