ESI-05
ESI-05 (NSC-116966) is a selective EPAC2 antagonist with an IC50 of 0.4 μM, effectively blocking cAMP-induced EPAC2 activation and subsequent Rap1 signaling. This tool compound is utilized in vitro and in vivo to investigate EPAC2's role in insulin secretion, neuronal function, and potential therapeutic applications for diabetes and neurological disorders.
Product Specifications
CAS Number
5184-64-5
Product Name Alternative
Diglyceride acyltransferase, Diacylglycerol acyltransferase, diabetes, acyl-CoA:cholesterol acyltransferase, Acyltransferase, cAMP, inhibit, Intracranial hemorrhage (ICH), NSC 116966, NSC116966, NSC-116966, Inhibitor, neurological disorders, insulin secretion, GEF, mono- acylglycerol acyltransferase, ESI 05, ESI05, ESI-05, EPAC2, exchange proteins directly activated by cAMP 2 (EPAC2)
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
97.22% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (12.03 mM) ; DMSO:83.33 mg/mL (303.7 mM)
Smiles
Cc1ccc (cc1) S (=O) (=O) c1c (C) cc (C) cc1C
Molecular Formula
C16H18O2S
Molecular Weight
274.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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