Rapamycin

Rapamycin is a natural macrolide and potent mTOR inhibitor, demonstrating high specificity with an IC50 of 0.1 nM in HEK293 cells. This compound is widely used in research for its immunosuppressive properties and ability to induce autophagy, applicable in both in vitro mechanistic studies and in vivo models of aging and disease.

Product Specifications

CAS Number

53123-88-9

Product Name Alternative

Sirolimus; AY-22989; WY-090217; NSC-226080; Rapamune

Field of Research

Cell Biology, Immunology & Inflammation

Purity

>98%

Bioactivity

MTOR inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml) .

Smiles

[H][C@@]12CC[C@@H] (C) [C@@] (O) (O1) C (=O) C (=O) N1CCCC[C@@]1 ([H]) C (=O) O[C@@] ([H]) (CC (=O) [C@H] (C) \C=C (C) \[C@@H] (O) [C@@H] (OC) C (=O) [C@H] (C) C[C@H] (C) \C=C\C=C\C=C (C) \[C@H] (C2) OC) [C@H] (C) C[C@@H]1CC[C@@H] (O) [C@@H] (C1) OC

Molecular Formula

C51H79NO13

Molecular Weight

914.2

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

(7E,15E,17E,19E) -9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[ (1R) -2-[ (1S,3R,4R) -4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29 (4H,6H,31H) -pentone