GANT 58
GANT 58 (NSC-75503) is a small molecule inhibitor that potently antagonizes the Gli transcription factor, specifically blocking GLI1-mediated transcriptional activity with an IC50 of 5 μM. This compound is a valuable research tool for studying Hedgehog signaling in cancer biology and has been utilized in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
64048-12-0
Product Name Alternative
Smoothened, Gli, Inhibitor, Hedgehog, GANT 58, GANT58, GANT-58, inhibit, NSC 75503, NSC75503, NSC-75503
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.27 mM) ; DMSO:9.09 mg/mL (23.16 mM)
Smiles
C1cc (ccn1) -c1sc (c (c1-c1ccncc1) -c1ccncc1) -c1ccncc1
Molecular Formula
C24H16N4S
Molecular Weight
392.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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