GNE-781
GNE-781 is a potent and selective CBP inhibitor with an IC50 of 0.94 nM, also showing activity against BRET and BRD4 (1) . This small molecule is a valuable chemical probe for epigenetic research, enabling the study of CBP/p300 function in cancer models and transcriptional regulation in both cellular and biochemical assays.
Product Specifications
CAS Number
1936422-33-1
Product Name Alternative
BRD4 (1), BRD41, CBP, BRET, inhibit, GNE781, GNE-781, GNE 781, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, HATs, HAT, Histone Acetyltransferase
Field of Research
Epigenetics & Chromatin
Purity
98.73% (May vary between batches)
Solubility
Ethanol:95 mg/mL (180.75 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.81 mM) ; DMSO:95 mg/mL (180.75 mM)
Smiles
CNC (=O) N1CCc2c (C1) c (nn2C1CCOCC1) N1CCCc2cc (-c3cnn (C) c3) c (cc12) C (F) F
Molecular Formula
C27H33F2N7O2
Molecular Weight
525.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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