GNF351
GNF351 is a potent and selective aryl hydrocarbon receptor (AHR) antagonist, effectively inhibiting both DRE-dependent and -independent signaling with an IC50 of 62 nM. It exhibits low cytotoxicity in keratinocytes and is a valuable research tool for studying AHR biology in inflammatory, toxicological, and oncological contexts, both in vitro and in vivo.
Product Specifications
CAS Number
1227634-69-6
Product Name Alternative
GNF 351, GNF351, GNF-351, Inhibitor, inhibit, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, aryl hydrocarbon receptor, AhR
Field of Research
Immunology & Inflammation
Purity
98.43% (May vary between batches)
Solubility
DMSO:124 mg/mL (301.34 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.72 mM)
Smiles
CC (C) n1cnc2c (NCCc3c[nH]c4ccccc34) nc (nc12) -c1cncc (C) c1
Molecular Formula
C24H25N7
Molecular Weight
411.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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