Dasatinib monohydrate
Dasatinib monohydrate is a potent, orally available SRC-family and BCR-ABL tyrosine kinase inhibitor. It is widely used in research to overcome imatinib resistance in CML models, with applications in both in vitro cellular assays and in vivo xenograft studies for investigating leukemia pathogenesis and treatment.
Product Specifications
CAS Number
863127-77-9
Product Name Alternative
WiDr, Src, prostate, K562, inhibit, PC3, orally, Inhibitor, EphA2, Ephrin Receptor, EphrinReceptor, Dasatinib, Dasatinib monohydrate, Dasatinib Monohydrate, colon, cKit, c-Kit (D816V), c-Kit (wt), CML, breast, active, Abl, antitumor, antiproliferative, Apoptosis, Autophagy, BMS 354825, BMS 354825 Monohydrate, BMS354825 Monohydrate, BMS-354825 Monohydrate, BMS354825, BMS-354825, BcrAbl, Bcr-Abl
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.68% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:123.75 mg/mL (244.55 mM)
Smiles
N1cc (sc1Nc1nc (nc (N2CCN (CC2) CCO) c1) C) C (=O) Nc1c (cccc1C) Cl.O
Molecular Formula
C22H28ClN7O3S
Molecular Weight
506.03
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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