Axitinib
Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 values of 4, 20, 0.4, and 2 nM for VEGFR1, VEGFR2, VEGFR3, and PDGFRβ, respectively. It exhibits significant antitumor activity and is an approved therapeutic for renal cell carcinoma, widely used in preclinical angiogenesis and oncology research both in vitro and in vivo.
Product Specifications
CAS Number
319460-85-0
Product Name Alternative
CKit, c-kit, Axitinib, AG 013736, AG013736, AG-013736, inhibit, PDGFRβ, Platelet-derived growth factor receptor, PDGFR, Inhibitor, VEGFR, VEGFR3, VEGFR2, VEGFR1, Vascular endothelial growth factor receptor
Field of Research
Cardiovascular Research
Purity
>98%
Bioactivity
VEGFR kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) .
Smiles
C (=C/C1=CC=CC=N1) \C=2C=3C (=CC (SC4=C (C (NC) =O) C=CC=C4) =CC3) NN2
Molecular Formula
C22H18N4OS
Molecular Weight
386.47
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-Methyl-[[3-[ (1E) -2- (2-pyridinyl) ethenyl]-1H-indazol-6-yl]thio]benzamide
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