BMS-986158
BMS-986158 is a potent and selective BET bromodomain inhibitor, exhibiting low nanomolar IC50 values in cellular assays, including 6.6 nM in NCI-H211 SCLC and 5 nM in MDA-MB-231 TNBC cells. It is a valuable chemical probe for oncology research, utilized in both in vitro and in vivo studies to investigate epigenetic mechanisms in cancer.
Product Specifications
CAS Number
1800340-40-2
Product Name Alternative
BET, BMS 986158, BMS986158, BMS-986158, Inhibitor, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit
Field of Research
Epigenetics & Chromatin
Purity
98.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.04 mM) ; DMSO:60 mg/mL (121.06 mM)
Smiles
Cc1nnn (C) c1-c1cnc2c (c1) n ([C@@H] (C1CCOCC1) c1ccccc1) c1cc (ccc21) C (C) (C) O
Molecular Formula
C30H33N5O2
Molecular Weight
495.62
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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