Deucravacitinib
Deucravacitinib (BMS-986165) is an oral, allosteric inhibitor that selectively targets the TYK2 pseudokinase (JH2) domain with high potency (IC50 = 1.0 nM) . It functions by stabilizing this regulatory domain, thereby blocking IL-12, IL-23, and type I interferon signaling pathways. This mechanism supports its research application in studying autoimmune disease models, both in vitro and in vivo.
Product Specifications
CAS Number
1609392-27-9
Product Name Alternative
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Purity
>99.99% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.76 mM) ; DMSO:84.2 mg/mL (197.9 mM)
Smiles
[2H]C ([2H]) ([2H]) NC (=O) c1nnc (NC (=O) C2CC2) cc1Nc1cccc (-c2ncn (C) n2) c1OC
Molecular Formula
C20H19D3N8O3
Molecular Weight
425.46
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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