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BTRX-335140

BTRX-335140 (CYM-53093) is a potent, selective, and orally bioavailable κ-opioid receptor (KOR) antagonist. It demonstrates high selectivity for KOR over μOR and δOR, with respective IC50 values of 0.8 nM, 110 nM, and 6500 nM. This compound is a valuable research tool for investigating KOR function in both in vitro assays and in vivo models of stress, addiction, and depression.

Product Specifications

CAS Number

2244614-14-8

Product Name Alternative

CNS, CYM 53093, CYM53093, CYM-53093, BTRX 335140, BTRX335140, BTRX-335140, inhibit, oral, OpioidReceptor, Opioid Receptor, neurobehavioral disorder, Inhibitor, U69593, U2OS, δ-opioid receptor, δOR, μ-opioid receptor, μOR, κ-opioid receptor, κOR

Field of Research

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Purity

98.00% (May vary between batches)

Solubility

DMSO:5.5 mg/mL (12.13 mM)

Smiles

CCc1cc (F) c2nc (N3CCC (CC3) NC3CCOCC3) c (-c3nc (C) no3) c (C) c2c1

Molecular Formula

C25H32FN5O2

Molecular Weight

453.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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