BTRX-335140
BTRX-335140 (CYM-53093) is a potent, selective, and orally bioavailable κ-opioid receptor (KOR) antagonist. It demonstrates high selectivity for KOR over μOR and δOR, with respective IC50 values of 0.8 nM, 110 nM, and 6500 nM. This compound is a valuable research tool for investigating KOR function in both in vitro assays and in vivo models of stress, addiction, and depression.
Product Specifications
CAS Number
2244614-14-8
Product Name Alternative
CNS, CYM 53093, CYM53093, CYM-53093, BTRX 335140, BTRX335140, BTRX-335140, inhibit, oral, OpioidReceptor, Opioid Receptor, neurobehavioral disorder, Inhibitor, U69593, U2OS, δ-opioid receptor, δOR, μ-opioid receptor, μOR, κ-opioid receptor, κOR
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:5.5 mg/mL (12.13 mM)
Smiles
CCc1cc (F) c2nc (N3CCC (CC3) NC3CCOCC3) c (-c3nc (C) no3) c (C) c2c1
Molecular Formula
C25H32FN5O2
Molecular Weight
453.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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