Methotrexate
Methotrexate is a folate analog and potent inhibitor of dihydrofolate reductase (DHFR), exhibiting antimetabolic and immunosuppressive properties. It is widely used in research areas including oncology, immunology, and rheumatology for in vitro cell-based assays and in vivo disease modeling.
Product Specifications
CAS Number
59-05-2
Product Name Alternative
Arthritis, antineoplastic, Apoptosis, Antifolate, Amethopterin, ADC Payload, ADC Cytotoxin, ADCCytotoxin, DNA, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, CL 14377, CL14377, CL-14377, immunosuppressant, inhibit, lymphoblastic, Methotrexate, NCI-C 04671, NCI-C04671, NCI-C-04671, Inhibitor, hDHFR (dihydrofolate reductase), leukemia, WR19039, WR-19039, WR 19039, reductase, RNA Synthesis, RNASynthesis, rheumatoid, synthesis
Field of Research
Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery
Purity
96.84% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:8.3 mg/mL (18.26 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:70 mg/mL (154.04 mM)
Smiles
NC=1C2=C (N=CC (CN (C) C3=CC=C (C (N[C@@H] (CCC (O) =O) C (O) =O) =O) C=C3) =N2) N=C (N) N1
Molecular Formula
C20H22N8O5
Molecular Weight
454.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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