Calicheamicin
Calicheamicin γ1 is a potent antitumor antibiotic that inhibits DNA synthesis by inducing cytotoxic double-strand DNA breaks. It is widely used as a payload in antibody-drug conjugates (ADCs) for targeted cancer therapy and serves as a critical tool in oncology research for studying DNA damage mechanisms in vitro and in vivo.
Product Specifications
CAS Number
108212-75-5
Product Name Alternative
Calicheamicin, Calicheamicin gamma1, Calicheamicin r1, Calicheamicin γ 1, Calicheamicin γ1, Calicheamicin γ-1, Calicheamicins, ADCCytotoxin, ADC Cytotoxin
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology
Purity
98.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (2.92 mM) ; DMSO:100 mg/mL (73.08 mM)
Smiles
[H][C@@]1 (C[C@H] (OC) [C@H] (CO1) NCC) O[C@@H]1[C@@H] (O) [C@H] (NO[C@H]2C[C@H] (O) [C@H] (SC (=O) c3c (C) c (I) c (O[C@@H]4O[C@@H] (C) [C@H] (O) [C@@H] (OC) [C@H]4O) c (OC) c3OC) [C@@H] (C) O2) [C@@H] (C) O[C@@]1 ([H]) O[C@H]1C#C\C=C/C#C[C@]2 (O) CC (=O) C (NC (=O) OC) =C1\C2=C\CSSSC
Molecular Formula
C55H74IN3O21S4
Molecular Weight
1368.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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