CBR-5884
CBR-5884 is a selective, time-dependent, noncompetitive inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. It disrupts PHGDH oligomerization, suppresses de novo serine synthesis, and demonstrates selective anti-proliferative activity in high-serine-biosynthesis cancer models like melanoma and breast cancer in vitro.
Product Specifications
CAS Number
681159-27-3
Product Name Alternative
Inhibitor, inhibit, CBR-5884, CBR 5884, CBR5884, serine synthesis, PHGDH
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Serine biosynthesis inhibitor (PHGDH inhibitor)
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml), or in DMF (up to 50 mg/ml) .
Smiles
CCOC (=O) c1sc (NC (=O) c2ccco2) c (SC#N) c1C
Molecular Formula
C14H12N2O4S2
Molecular Weight
336.39
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Ethyl 5- (furan-2-carboxamido) -3-methyl-4-thiocyanatothiophene-2-carboxylate
Available Sizes
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