Tucatinib
Tucatinib (ONT-380) is a highly selective small molecule inhibitor of HER2 with an IC50 of 8 nM. It is widely used in preclinical research, including in vitro cell studies and in vivo models, to investigate targeted therapies for HER2-positive cancers such as breast and colorectal malignancies.
Product Specifications
CAS Number
937263-43-9
Product Name Alternative
Tucatinib, ARRY 380, ARRY380, ARRY-380, Inhibitor, HER2/ErbB2, HER1, EGFR, Epidermal growth factor receptor, ErbB-1, inhibit, Irbinitinib, p95 HER2, ONT 380, ONT380, ONT-380
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.05% (May vary between batches)
Solubility
Ethanol:15 mg/mL (31.22 mM) ; DMSO:45 mg/mL (93.65 mM)
Smiles
Cc1cc (Nc2ncnc3ccc (NC4=NC (C) (C) CO4) cc23) ccc1Oc1ccn2ncnc2c1
Molecular Formula
C26H24N8O2
Molecular Weight
480.52
Storage Conditions
-20°C
Notes
For research use only.
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