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SKF-86002

SKF-86002 is a potent and cell-permeable p38 MAP kinase inhibitor with an IC50 of 0.5-1 μM. It effectively suppresses LPS-induced production of pro-inflammatory cytokines IL-1 and TNF-α in human monocytes. This compound is a valuable tool for investigating p38 signaling in inflammatory disease models, both in vitro and in vivo.

Product Specifications

CAS Number

72873-74-6

Product Name Alternative

Lipoxygenase, inhibit, p38 MAPK, p38MAPK, metabolism, Inhibitor, cyclooxygenase, 5-lipoxygenase, acid, anti-arthritic, anti-inflammatory, analgesic, arachidonic, SKF86002, SKF-86002, SKF 86002, TNF-α

Field of Research

Cell Biology, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

DMSO:Slightly soluble

Smiles

Fc1ccc (cc1) -c1nc2SCCn2c1-c1ccncc1

Molecular Formula

C16H12FN3S

Molecular Weight

297.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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