SKF-86002
SKF-86002 is a potent and cell-permeable p38 MAP kinase inhibitor with an IC50 of 0.5-1 μM. It effectively suppresses LPS-induced production of pro-inflammatory cytokines IL-1 and TNF-α in human monocytes. This compound is a valuable tool for investigating p38 signaling in inflammatory disease models, both in vitro and in vivo.
Product Specifications
CAS Number
72873-74-6
Product Name Alternative
Lipoxygenase, inhibit, p38 MAPK, p38MAPK, metabolism, Inhibitor, cyclooxygenase, 5-lipoxygenase, acid, anti-arthritic, anti-inflammatory, analgesic, arachidonic, SKF86002, SKF-86002, SKF 86002, TNF-α
Field of Research
Cell Biology, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:Slightly soluble
Smiles
Fc1ccc (cc1) -c1nc2SCCn2c1-c1ccncc1
Molecular Formula
C16H12FN3S
Molecular Weight
297.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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