Ponatinib
Ponatinib is an orally active multi-targeted kinase inhibitor that potently inhibits Abl, PDGFRα, VEGFR2, FGFR1, and Src. It is used in research on chronic myeloid leukemia, demonstrating antitumor activity in both in vitro cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
943319-70-8
Product Name Alternative
AP-24534
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
Pan-Bcr-Abl and multikinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 50 mg/ml) ; or Ethanol (25 mg/ml, warm)
Smiles
C (#CC1=CC (C (NC2=CC (C (F) (F) F) =C (CN3CCN (C) CC3) C=C2) =O) =CC=C1C) C=4N5C (=NC4) C=CC=N5
Molecular Formula
C29H27F3N6O
Molecular Weight
532.6
References & Citations
MS Farhan Chemical Synthesis and Pharmacological Testing of Novel CXCL12 Inhibitors with Characterisation of Signalling Pathways Regulating CXCL12 Expression in Bone Cancer stax.strath.ac.uk, (2025)
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3- (2-Imidazo[1,2-b]pyridazin-3-ylethynyl) -4-methyl-N-[4-[ (4-methyl-1-piperazinyl) methyl]-3- (trifluoromethyl) phenyl]-benzamide
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