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RGB-286638 free base

RGB-286638 free base is a potent and selective cyclin-dependent kinase (CDK) inhibitor, exhibiting single-digit nM IC50 values against CDK1, CDK2, CDK3, CDK4, CDK5, and CDK9, with reduced activity against CDK6 and CDK7. This tool compound is used in biochemical and cellular research to investigate CDK function in cell cycle progression, transcription, and associated diseases.

Product Specifications

CAS Number

784210-88-4

Product Name Alternative

Cyclin dependent kinase, CDK2/cyclinE, CDK3/cyclinE, CDK4/cyclinD1, CDK9/cyclin T1, CDK1/cyclinB1, CDK, Janus kinase, JAK, inhibit, Mitogen-activated protein kinase kinase, MAP2K, MAPKK, MEK, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, p35-CDK5, RGB 286638, RGB 286638 free base, RGB286638, RGB-286638, RGB286638 free base, RGB-286638 free base

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

97.29% (May vary between batches)

Solubility

0.1M HCl:1 mg/mL (1.83 mM) ;15% Solutol HS-15 in Saline:10 mg/mL (18.33 mM) ; DMSO:Slightly soluble

Smiles

COCCN1CCN (Cc2ccc (cc2) -c2n[nH]c3-c4cccc (NC (=O) NN5CCOCC5) c4C (=O) c23) CC1

Molecular Formula

C29H35N7O4

Molecular Weight

545.63

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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