Abemaciclib
Abemaciclib is a potent and selective CDK4/6 inhibitor (IC50=2/10 nM) with demonstrated antitumor activity. It is widely used in cancer research, particularly for studying advanced breast cancer, and has been validated in both in vitro cell proliferation assays and in vivo xenograft models.
Product Specifications
CAS Number
1231929-97-7
Product Name Alternative
Cyclin dependent kinase, CDK, CDK6, CDK4, CDK4/6 dual inhibitor, Abemaciclib, inhibit, LY 2835219, LY2835219, LY-2835219, Inhibitor
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.39% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:1.69 mg/mL (3.34 mM) ;10% DMSO+90% Saline:0.1 mg/mL (0.2 mM)
Smiles
C (C) (C) N1C=2C (=C (F) C=C (C2) C3=NC (NC4=CC=C (CN5CCN (CC) CC5) C=N4) =NC=C3F) N=C1C
Molecular Formula
C27H32F2N8
Molecular Weight
506.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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