Heclin
Heclin is a cell-permeable small molecule inhibitor targeting the HECT domain of E3 ubiquitin ligases, including Smurf2, Nedd4, and WWP1, with IC50 values ranging from 6.3 to 6.9 μM. It is a valuable research tool for studying ubiquitination pathways in cellular and biochemical assays, applicable in cancer and developmental biology research.
Product Specifications
CAS Number
890605-54-6
Product Name Alternative
E1Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1 activating enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3 ligating enzyme, E3Enzyme, inhibit, HECT E3 ubiquitin ligase, Heclin, Inhibitor, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme
Field of Research
Cell Biology, Protein Biochemistry
Purity
>98%
Bioactivity
HECT domain containing E3 ubiquitin ligase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml) .
Smiles
CCc1ccc (\C=C\C (=O) Nc2ccc (cc2) C (C) =O) o1
Molecular Formula
C17H17NO3
Molecular Weight
283.33
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2E-N- (4-Acetylphenyl) -3- (5-ethylfuran-2-yl) prop-2-enamide
Available Sizes
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