PP121
PP-121 is a potent multi-kinase inhibitor targeting PDGFR, Hck, mTOR, VEGFR2, Src, and Abl with low nanomolar IC50 values, and also inhibits DNA-PK. It has been utilized in preclinical research to study oncogenic signaling pathways and has shown activity in cellular proliferation assays and in vivo tumor models.
Product Specifications
CAS Number
1092788-83-4
Product Name Alternative
Apoptosis, BcrAbl, Abl, Mammalian target of Rapamycin, Inhibitor, Hck, inhibit, mTOR, Platelet-derived growth factor receptor, PDGFR, PP 121, PP121, PP-121, Src, Vascular endothelial growth factor receptor, VEGFR
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.45% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:2 mg/mL (6.26 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.26 mM) ; DMSO:60 mg/mL (187.88 mM)
Smiles
Nc1ncnc2n (nc (-c3cnc4[nH]ccc4c3) c12) C1CCCC1
Molecular Formula
C17H17N7
Molecular Weight
319.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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