IHR-1
IHR-1 is a potent and selective Smoothened (Smo) antagonist with an IC50 of 7.6 nM, specifically inhibiting the Hedgehog signaling pathway. It blocks Smo accumulation in the primary cilium in vitro and is used in research studying developmental biology and cancer, including in vivo models of medulloblastoma and basal cell carcinoma.
Product Specifications
CAS Number
548779-60-8
Product Name Alternative
ShhN, SAG, Smo, Smoothened, Gli, IHR 1, IHR1, IHR-1, Inhibitor, inhibit
Field of Research
Stem Cell & Developmental Biology
Purity
97.02% (May vary between batches)
Solubility
DMSO:25 mg/mL (55.05 mM)
Smiles
Clc1ccc (Cl) c (c1) C (=O) Nc1ccc (NC (=O) c2cc (Cl) ccc2Cl) cc1
Molecular Formula
C20H12Cl4N2O2
Molecular Weight
454.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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