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IHR-1

IHR-1 is a potent and selective Smoothened (Smo) antagonist with an IC50 of 7.6 nM, specifically inhibiting the Hedgehog signaling pathway. It blocks Smo accumulation in the primary cilium in vitro and is used in research studying developmental biology and cancer, including in vivo models of medulloblastoma and basal cell carcinoma.

Product Specifications

CAS Number

548779-60-8

Product Name Alternative

ShhN, SAG, Smo, Smoothened, Gli, IHR 1, IHR1, IHR-1, Inhibitor, inhibit

Field of Research

Stem Cell & Developmental Biology

Purity

97.02% (May vary between batches)

Solubility

DMSO:25 mg/mL (55.05 mM)

Smiles

Clc1ccc (Cl) c (c1) C (=O) Nc1ccc (NC (=O) c2cc (Cl) ccc2Cl) cc1

Molecular Formula

C20H12Cl4N2O2

Molecular Weight

454.13

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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