PNU-282987
PNU-282987 is a potent and selective agonist for the α7 nicotinic acetylcholine receptor (α7 nAChR), exhibiting a Ki of 26 nM. It shows negligible affinity for α1β1γδ and α3β4 nAChR subtypes (IC50 ≥ 60 μM) . This compound is widely used in neuroscience research to investigate α7 nAChR function in cognitive and neuropsychiatric disorders, both in vitro and in vivo.
Product Specifications
CAS Number
123464-89-1
Product Name Alternative
Inhibit, nAChR, Nicotinic acetylcholine receptors, Inhibitor, α7 nAChR, PNU282987, PNU-282987, PNU 282987
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.00% (May vary between batches)
Solubility
H2O:25 mg/mL (83 mM) ;10% DMSO+90% Corn Oil:1.67 mg/mL (5.54 mM) ; DMSO:250 mg/mL (829.99 mM)
Smiles
Cl.C1CN2CCC1[C@H] (C2) NC (=O) c1ccc (cc1) Cl
Molecular Formula
C14H18Cl2N2O
Molecular Weight
301.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific), CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RETGC-1, ROS-GC1, retGC) (AP)
GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific), CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RETGC-1, ROS-GC1, retGC) (AP)
