Olverembatinib dimesylate
Olverembatinib dimesylate is an orally active small molecule inhibitor targeting both wild-type Bcr-Abl and the T315I mutant. It is used in research for chronic myeloid leukemia, demonstrating activity in cellular assays and in vivo models of resistant disease.
Product Specifications
CAS Number
1421783-64-3
Product Name Alternative
Abl, Abl (E255K), Abl (H396P), Abl (M351T), Abl (Q252H), Bcr-Abl, Bcr-Abl (T315I), BcrAbl, breakpoint, cluster, nonphosphorylated, linase, inhibit, imatinib, Olverembatinib, Olverembatinib dimesylate, Olverembatinib Dimesylate, HQP 1351, HQP1351, HQP-1351, HQP1351 dimesylate, Inhibitor, GZD 824, GZD 824 Dimesylate, GZD824, GZD-824, GZD824 Dimesylate, GZD-824 Dimesylate, region-Abelson, phosphorylated, resistance
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.66% (May vary between batches)
Solubility
DMSO:93 mg/mL (128.32 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:92 mg/mL (126.94 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.55 mM)
Smiles
CS (O) (=O) =O.CS (O) (=O) =O.CN1CCN (Cc2ccc (NC (=O) c3ccc (C) c (c3) C#Cc3cnc4[nH]ncc4c3) cc2C (F) (F) F) CC1
Molecular Formula
C29H27F3N6O·2CH4O3S
Molecular Weight
724.77
Storage Conditions
-20°C
Notes
For research use only.
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