EPZ011989
EPZ011989 is a potent, selective, and orally bioavailable inhibitor of EZH2, with sub-nanomolar affinity for both wild-type and Y646 mutant forms. It demonstrates high selectivity over EZH1 and other histone methyltransferases. This compound is a valuable chemical probe for studying PRC2 function in cancer models, including lymphoma, both in vitro and in vivo.
Product Specifications
CAS Number
1598383-40-4
Product Name Alternative
Inhibit, EZH2, EPZ 011989, EPZ011989, EPZ-011989, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor
Field of Research
Epigenetics & Chromatin
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.65 mM) ; Ethanol:100 mg/mL (165.07 mM) ; DMSO:3.8 mg/mL (6.27 mM)
Smiles
CCN ([C@H]1CC[C@@H] (CC1) N (C) CCOC) c1cc (cc (C (=O) NCc2c (C) cc (C) [nH]c2=O) c1C) C#CCN1CCOCC1
Molecular Formula
C35H51N5O4
Molecular Weight
605.81
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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