IC261

IC261 (SU-5607) is a selective casein kinase 1 (CK1) inhibitor with an IC50 of 16 μM, which is significantly more potent than its activity against Cdk5 (IC50 4.5 mM) . It activates the mitotic checkpoint and is widely used in vitro to study cell cycle regulation, apoptosis, and circadian rhythms.

Product Specifications

CAS Number

186611-52-9

Product Name Alternative

CDK5, CK1, Casein Kinase, CaseinKinase, Apoptosis, inhibit, Inhibitor, IC-261, IC261, IC 261, SU 5607, SU5607, SU-5607

Field of Research

Cell Biology, Metabolism Research, Stem Cell & Developmental Biology

Purity

98.77% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.42 mM) ; DMSO:70 mg/mL (224.84 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)