CI-1040
CI-1040 (PD184352) is a potent and selective, ATP-noncompetitive inhibitor of MEK1 and MEK2 with an IC50 of 17 nM. This compound is a valuable research tool for investigating the MAPK/ERK pathway in both in vitro cellular assays and in vivo models of cancer and other proliferative diseases.
Product Specifications
CAS Number
212631-79-3
Product Name Alternative
CI1040, CI-1040, CI 1040, Apoptosis, Mitogen-activated protein kinase kinase, PD 184352, PD184352, PD-184352, inhibit, Inhibitor, MAPKK, MEK2, MEK1, MEK, MAP2K
Field of Research
Cell Biology, Signal Transduction
Purity
99.10% (May vary between batches)
Solubility
Ethanol:12 mg/mL (25.07 mM) ; DMSO:125 mg/mL (261.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.18 mM)
Smiles
Fc1ccc (C (=O) NOCC2CC2) c (Nc2ccc (I) cc2Cl) c1F
Molecular Formula
C17H14ClF2IN2O2
Molecular Weight
478.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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