FG-2216
FG-2216 (YM-311) is a potent, orally bioavailable inhibitor of HIF-prolyl hydroxylase 2 (PHD2/EGLN1) with an IC50 of 3.9 μM. It is a research tool for studying hypoxia signaling and has been shown to induce significant, reversible erythropoietin (Epo) production in vivo.
Product Specifications
CAS Number
223387-75-5
Product Name Alternative
PHD2, YM 311, prolyl, YM311, YM-311, inhibit, IOX 3, IOX3, IOX-3, erythropoietin, fetal, FG2216, FG-2216, FG 2216, Hypoxia-inducible factors, hydroxylase, Inhibitor, hemoglobin, HIF, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIFs, HIFProlylHydroxylase, HIF-PH
Field of Research
Epigenetics & Chromatin, Metabolism Research
Purity
96.46% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:50 mg/mL (178.15 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (8.91 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
OC (=O) CNC (=O) c1nc (Cl) c2ccccc2c1O
Molecular Formula
C12H9ClN2O4
Molecular Weight
280.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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