D4476
D4476 is a potent, selective, and cell-permeable inhibitor of casein kinase 1 (CK1), exhibiting an IC50 of 300 nM. This small molecule is widely used in biochemical and cellular research to probe CK1 signaling in pathways such as Wnt/β-catenin and circadian rhythms, both in vitro and in vivo.
Product Specifications
CAS Number
301836-43-1
Product Name Alternative
ALK5, CaseinKinase, Casein Kinase I Inhibitor, Casein Kinase, Apoptosis, Autophagy, CK1δ, CK1, D4476, D-4476, D 4476, Inhibitor, inhibit
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.02% (May vary between batches)
Solubility
DMSO:62.5 mg/mL (156.87 mM) ; Ethanol:19.9 mg/mL (49.95 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM)
Smiles
NC (=O) c1ccc (cc1) -c1nc (c ([nH]1) -c1ccccn1) -c1ccc2OCCOc2c1
Molecular Formula
C23H18N4O3
Molecular Weight
398.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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