SANT-1
SANT-1 is a potent and selective small molecule antagonist of the Smoothened (Smo) receptor, binding with high affinity (Kd: 1.2 nM) and effectively blocking agonist activity (IC50: 20 nM) . This inhibitor is a valuable chemical tool for investigating Hedgehog signaling pathway mechanisms in both cellular and animal models of cancer and developmental biology.
Product Specifications
CAS Number
304909-07-7
Product Name Alternative
Inhibit, Inhibitor, Hedgehog, Smo, Smoothened, SANT1, SANT-1, SANT 1
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.84% (May vary between batches)
Solubility
DMSO:18.7 mg/mL (50.07 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.35 mM) ; Ethanol:9.3 mg/mL (24.9 mM)
Smiles
Cc1nn (c (C) c1C=NN1CCN (Cc2ccccc2) CC1) -c1ccccc1
Molecular Formula
C23H27N5
Molecular Weight
373.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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