Tivozanib
Tivozanib (KRN951) is an orally active small molecule inhibitor targeting VEGFR-1, -2, and -3. It exhibits potent antiangiogenic activity and is widely used in preclinical oncology research, including in vitro kinase assays and in vivo xenograft models for various solid tumors.
Product Specifications
CAS Number
475108-18-0
Product Name Alternative
Angiogenesis, antitumor, AV 951, AV951, AV-951, Inhibitor, EphB2, Ephrin Receptor, EphrinReceptor, inhibit, KRN 951, KRN951, KRN-951, orally active, VEGFR2, VEGFR1, VEGFR, VEGFR3, vascular permeability, Vascular endothelial growth factor receptor, PDGFRα, Tivozanib, renal cell carcinoma
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.41% (May vary between batches)
Solubility
DMSO:38.33 mg/mL (84.27 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.4 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
O (C=1C2=C (C=C (OC) C (OC) =C2) N=CC1) C3=CC (Cl) =C (NC (NC=4C=C (C) ON4) =O) C=C3
Molecular Formula
C22H19ClN4O5
Molecular Weight
454.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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