GSK2656157
GSK2656157 is a potent and highly selective ATP-competitive inhibitor of PERK, demonstrating an IC50 of 0.9 nM in biochemical assays with over 500-fold selectivity across 300 kinases. This tool compound is widely used in vitro and in vivo to investigate the unfolded protein response, ER stress signaling, and related pathologies such as cancer and neurodegenerative diseases.
Product Specifications
CAS Number
1337532-29-2
Product Name Alternative
Autophagy, Apoptosis, Inhibitor, GSK2656157, GSK-2656157, GSK 2656157, inhibit, PERK, Protein kinase R-like endoplasmic reticulum kinase, PKR-like endoplasmic reticulum kinase
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
PERK inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml with warming)
Smiles
Cc1cccc (CC (=O) N2CCc3c2ccc (-c2cn (C) c4ncnc (N) c24) c3F) n1
Molecular Formula
C23H21FN6O
Molecular Weight
416.5
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1-[5- (4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl) -4-fluoro-2,3-dihydroindol-1-yl]-2- (6-methylpyridin-2-yl) ethanone
Available Sizes
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