Crenolanib
Crenolanib (ARO 002) is an orally active, potent type III tyrosine kinase inhibitor targeting PDGFRα/β and FLT3 with low nanomolar IC50 values. It is widely used in preclinical research for studying acute myeloid leukemia (AML) and solid tumors, demonstrating activity in both in vitro cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
670220-88-9
Product Name Alternative
CP-868,596
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
>97%
Form
Powder
Solubility
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml_
Smiles
CC1 (COc2ccc3n (cnc3c2) -c2ccc3cccc (N4CCC (N) CC4) c3n2) COC1
Molecular Formula
C26H29N5O2
Molecular Weight
443.55
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1-[2-[5-[ (3-Methyloxetan-3-yl) methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine
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