KN-62
KN-62 is a selective cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.9 μM. It is widely used in neuroscience and cardiovascular research to probe CaMKII signaling in cellular models and animal studies of synaptic plasticity, cardiac function, and memory.
Product Specifications
CAS Number
127191-97-3
Product Name Alternative
Inhibitor, HEK293 cells, inhibit, KN 62, KN62, KN-62, noncompetitive antagonism, autophosphorylation, Autophagy, Calmodulin-dependent protein kinases, Calmodulin-dependent kinases, CaMK, CaMKII, CaMKV, P2X Receptor, P2XReceptor, P2XRs
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery
Purity
98.77% (May vary between batches)
Solubility
DMSO:125 mg/mL (173.17 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.77 mM)
Smiles
O=C ([C@H] (Cc1ccc (OS (=O) (=O) c2cccc3cnccc23) cc1) NCS (=O) (=O) c1cccc2cnccc12) N1CCN (CC1) c1ccccc1
Molecular Formula
C38H35N5O6S2
Molecular Weight
721.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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