DDD85646

DDD85646 is a potent and selective inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT), exhibiting sub-nanomolar binding affinity (Ki=1.44 nM) and potent activity against the parasite (EC50=2 nM) . It shows selectivity over human NMT (IC50=4 nM), making it a valuable chemical probe for studying trypanosomatid biology and for anti-parasitic drug discovery research in both in vitro and in vivo models.