Difamilast
Difamilast is a potent and selective PDE4 inhibitor, demonstrating high specificity for the PDE4B subtype with an IC50 of 11.2 nM. This small molecule is a valuable research tool for investigating PDE4-related pathways in inflammatory and autoimmune diseases, applicable in both cellular and animal model studies.
Product Specifications
CAS Number
937782-05-3
Product Name Alternative
Subtype, Phosphodiesterase (PDE), phosphodiesterase-4, atopic, Difamilast, dermatitis, Inhibitor, inhibit, PDE4B, OPA 15406, OPA15406, OPA-15406, PDE4
Field of Research
Metabolism Research
Purity
99.04% (May vary between batches)
Solubility
DMSO:100 mg/mL (223.99 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.39 mM)
Smiles
CCOc1ccccc1C (=O) NCc1coc (n1) -c1ccc (OC (F) F) c (OC (C) C) c1
Molecular Formula
C23H24F2N2O5
Molecular Weight
446.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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