Gossypol (acetic acid)
Gossypol acetic acid (AT101) is a cottonseed-derived polyphenol that functions as a pan-Bcl-2 inhibitor by binding to Bcl-2, Bcl-xL, and Mcl-1, while sparing the BIR3 domain and BID. It is widely used in cancer research, particularly in studies of apoptosis, with applications in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
12542-36-8
Product Name Alternative
Pogosin, inhibit, Gossypol, Gossypol (acetic acid), Gossypol acetic acid, Gossypol-acetic acid, Inhibitor, acetic acid, (±) -Gossypol-acetic acid, Bcl-2, Bcl-2 Family, BL-193 (acetic acid), AT101, AT-101, AT 101
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
96.76% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:2 mg/mL (3.46 mM) ; DMSO:100 mg/mL (172.83 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.91 mM)
Smiles
CC (O) =O.CC (C) c1c (O) c (O) c (C=O) c2c (O) c (c (C) cc12) -c1c (C) cc2c (C (C) C) c (O) c (O) c (C=O) c2c1O
Molecular Formula
C32H34O10
Molecular Weight
578.61
Storage Conditions
-20°C
Notes
For research use only.
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