GDC0575 monohydrochloride
GDC-0575 monohydrochloride (ARRY-575) is a highly potent and selective Chk1 inhibitor (IC50 = 1.2 nM) . It disrupts Chk1-mediated cell cycle checkpoints, forcing DNA-damaged cells into mitosis. This mechanism is applied in preclinical cancer research, particularly in combination with DNA-damaging agents, to study chemosensitization in vitro and in vivo models.
Product Specifications
CAS Number
1196504-54-7
Product Name Alternative
Chk1, ARRY575, ARRY-575, ARRY 575, GDC 0575, GDC 0575 Monohydrochloride, GDC0575, GDC-0575, GDC0575 Monohydrochloride, GDC0575 monohydrochloride, GDC-0575 Monohydrochloride, GDC-0575 monohydrochloride
Field of Research
Cell Biology
Purity
97.85% (May vary between batches)
Solubility
DMSO:60 mg/mL (144.67 mM)
Smiles
O=C (C1CC1) NC2=CNC3=NC=C (Br) C (N4C[C@H] (N) CCC4) =C32.[H]Cl
Molecular Formula
C16H21BrClN5O
Molecular Weight
414.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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